CLOFARABINE
Κλοφαραβίνη
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed in the U.S. and Canada as Clolar. In Europe and Australia/New Zealand the product is …
Φαρμακολογικό Προφίλ
Περιγραφή & Ένδειξη
Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed in the U.S. and Canada as Clolar. In Europe and Australia/New Zealand the product is marketed under the name Evoltra. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaemia (ALL), only after at least two other types of treatment have failed. It is not known if the drug extends life expectancy. Some investigations of effectiveness in cases of acute myeloid leukaemia (AML) and juvenile myelomonocytic leukaemia (JMML) have been carried out.
Κύρια Ένδειξη
Χρόνος Ημιζωής
The terminal half-life is estimated to be 5.2 hours.
Σύνδεση Πρωτεϊνών
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Μηχανισμός Δράσης
Clofarabine is metabolized intracellularly to the active 5'-monophosphate metabolite by deoxycytidine kinase and 5'-triphosphate metabolite by mono- …
Οδός Αποβολής
Based on 24-hour urine collections in the pediatric studies, 49 - 60% of the dose is excreted in the urine unchanged.
Όγκος Κατανομής
* 172 L/m2
Κατηγορίες ATC
Βρείτε τη δραστική μέσα από τις αντίστοιχες κατηγορίες ATC level 5.
Διαθέσιμα Σκευάσματα
Εγκεκριμένα φαρμακευτικά σκευάσματα που περιέχουν CLOFARABINE.
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