←

Αντιβιοτικά

clinio.gr
Αναζήτηση σε όλο το site
ATC CODE H01AC03

MECASERMIN

Μεκασερμίνη

Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a …

Chemical structure of MECASERMIN

Φαρμακολογικό Προφίλ

Πηγή: DrugBank

Περιγραφή & Ένδειξη

Mecasermin contains recombinant-DNA-engineered human insulin-like growth factor-1 (rhIGF-1). IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges and a molecular weight of 7649 daltons. The amino acid sequence of the product is identical to that of endogenous human IGF-1. The rhIGF-1 protein is synthesized in bacteria (E. coli) that have been modified by the addition of the gene for human IGF-1.

Κύρια Ένδειξη

For the long-term treatment of growth failure in pediatric patients with Primary IGFD or with GH gene deletion who have developed neutralizing antibodies to GH. It is not indicated to treat Secondary IGFD resulting from GH deficiency, malnutrition, hypothyroidism or other causes; it is not a substitute for GH therapy.

Χρόνος Ημιζωής

2h

2 hours

Σύνδεση Πρωτεϊνών

In blood, IGF-1 is bound to six IGF binding proteins, with > 80% bound as a complex with IGFBP-3 and an acid-labile subunit.

Δείτε αναλυτικό φαρμακολογικό προφίλ.

+ Περισσότερες Φαρμακολογικές Πληροφορίες

Μηχανισμός Δράσης

Mecasermin supplies recombinant-DNA-origin IGF-1, which binds to the Type I IGF-1 receptor. This receptor exerts intra-cellular signaling activity in …

Οδός Αποβολής

Both the liver and the kidney have been shown to metabolize IGF-1.

Όγκος Κατανομής

* 0.257 ± 0.073 L/kg [subjects with severe Primary IGFD]

Κατηγορίες ATC

Βρείτε τη δραστική μέσα από τις αντίστοιχες κατηγορίες ATC level 5.

ATC Level 5
H01AC03

Μεκασερμίνη

›

Διαθέσιμα Σκευάσματα

Εγκεκριμένα φαρμακευτικά σκευάσματα που περιέχουν MECASERMIN.

Φόρτωση σκευασμάτων...