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ΔΡΑΣΤΙΚΗ ΟΥΣΙΑ V08AB01 SPC ΕΟΦ DrugBank PubChem Σκευάσματα

METRIZAMIDE

For lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (CNS) as well as for cisternography by direct injection using standard radiologic techniques to visualize the …

Chemical structure of METRIZAMIDE

Κλινική Σύνοψη

Προτεραιότητα πηγών: SPC, ΕΟΦ, DrugBank

Curated
clinical_notes
DrugBank

Ενδείξεις

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For lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (CNS) as well as for cisternography by direct injection using standard radiologic…
neurology
DrugBank

Μηχανισμός δράσης

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Organic iodine compounds such as metrizamide block x-rays as they pass through the body, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these…
monitor_heart
PubChem

Φαρμακοδυναμική

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Φαρμακοδυναμική Η μετριζαμίδη είναι ένας ραδιοσκιαγραφικός παράγοντας που χρησιμοποιείται για τη βελτίωση της αντίθεσης των εσωτερικών δομών του σώματος με τη χρήση διαφορετικών απεικονιστικών τεχνικών, όπως οι αξονικές τομογραφίες (CT) ή η ακτινογραφία…
biotech
PubChem

Φαρμακοκινητική

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Απορρόφηση, Κατανομή & Απέκκριση Η απορρόφηση από το γαστρεντερικό σωλήνα είναι αμελητέα μετά από από του στόματος ή ορθική χορήγηση.
bloodtype
PubChem

Απέκκριση

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Απορρόφηση, Κατανομή & Απέκκριση Η απορρόφηση από το γαστρεντερικό σωλήνα είναι αμελητέα μετά από από του στόματος ή ορθική χορήγηση.

Σκευάσματα & Τιμολόγηση

Δεδομένα ΕΟΦ (04/2026)
Φόρτωση...

Μονογραφίες Πηγών

Αναλυτικό περιεχόμενο ανά πηγή για τεκμηρίωση και έλεγχο

DrugBank

Description

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A solute for density gradient centrifugation offering higher maximum solution density without the problems of increased viscosity. It is also used as a resorbable, non-ionic contrast medium.
DrugBank

Indication

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For lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (CNS) as well as for cisternography by direct injection using standard radiologic techniques to visualize the basal cistern of the brain. For computerized tomography (CT) of the intracranial subarachnoid spaces and for ventriculography by direct injection using standard radiologic techniques to visualize the cerebral ventricles. Also used in pediatric angiocardiography to visualize lesions or malformations of the heart and obstructions or anomalies of the major thoracic vessels. Also used in adult peripheral arteriography to visualize specific regions of the vascular system and blood flow in such areas to help in the diagnosis and evaluation of neoplasms (known or suspected) or vascular diseases (congenital or acquired) that may cause changes in normal vascular anatomy or physiology. Metrizamide is also indicated in adults for intravenous digital arteriography of head and neck.
DrugBank

Mechanism of action

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Organic iodine compounds such as metrizamide block x-rays as they pass through the body, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. After intrathecal administration into the subarachnoid space, diffusion of metrizamide in the CSF allows the visualization of the subarachnoid spaces of the head and spinal canal. After intravascular administration, metrizamide makes opaque those vessels in its path of flow, allowing visualization of the internal structures until significant hemodilution occurs.
DrugBank

Absorption

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Absorption from gastrointestinal tract is negligible following oral or rectal administration.

Scientific Profile

CID
443944
Μοριακός τύπος
C18H22I3N3O8
Μοριακό βάρος
789.1
IUPAC
3-acetamido-5-[acetyl(methyl)amino]-2,4,6-triiodo-N-[(3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]benzamide
InChIKey
BAQCROVBDNBEEB-UBYUBLNFSA-N
Κατάταξη MeSH

Ταξινόμηση MeSH

Ουσίες που χρησιμοποιούνται για βελτιωμένη οπτικοποίηση ιστών.

Σχετικά Εργαλεία